The multifunctional medical installation
The multifunctional medical installation can be used in personal households and hotels, for the hygiene and revitalization of the body through bathing and vibratory massage, and also in medical units, for physiotherapy through mud bathing or salts solutions, and through the exposure of the ailing parts of the body to an intense electromagnetic wave. Nowadays, there are various types of electromagnetic massage systems, which, although having a relatively simple construction scheme, have solid vibrating pieces, pretty uncomfortable when in contact with the human body, and with uncorrelated and limited to small areas actions.
The new technical solution eliminates these disadvantages, because the electromagnetic vibratory massage device has a plane reinforcement on which there is an electric winding with two or more phases for producing a progressive magnetic field, of translation on the direction of the succession of phases, which produces mechanical waves in a ferrofluid pillow placed near it. The technical problem solved by this design is represented by the construction of a multifunctional electromagnetic device that assures the hygiene of the body and also its massage through mechanic waves produced in a mass of ferrofluid and the treatment of some affections of the body through the positive effect of some physical and chemical factors, like:
- highly concentrated salts solutions;
- thermal and pressure gradients;
- complex magnetic field configurations;
- electromotive tensions and induced currents.
The progressive magnetic field for the translation on the direction of the succession of phases can be generated by a tri-phase winding placed in the notches of a plane reinforcement that represents the ferromagnetic holder.
The electric circuits for each phase of the alimentation tension are formed of reels placed in series and alternatively wrapped in one sense and the other.
The beginning extremities of the phase windings are tied separately to the electric alimentation terminals, while the end extremities of the phase windings are connected together to the null conductor.
The electric alimentation is done through a star assembly, from the tri-phase alternative current network through some transformers with median plugs equipped with tri-phase switches, and some frequency switches, for the optimization of the function regime through the adjustment of the electric parameters.
The electric current from the tri-phase winding produces a progressive electric field, for the translation on the direction of the succession of phases, whose magnetic induction in the vicinity of the reinforcement can be approximate through the relation: B(x,t) ≈ Bmsin(ωt - 2πx/d), in which:
Bm = the maximum value or the amplitude of the magnetic induction;
ω = the pulsation of the alternative current;
x = coordinate of the current point on a longitude reference axis oriented in the sense of the phase succession;
d = the distance between two successive points, when the magnetic induction vector swings in phase.
The resulting translation magnetic field, interacting with the ferrofluid mass, produces mechanical waves with a double frequency that assures the vibratory massage function of the prototype electromagnetic device.
Another positive effect of the variable magnetic field, with implications in physiotherapy, is the induction in an average conductor, for instance a highly concentrated salts solution, of some electromotive tensions, and implicitly, of some electric currents whose amplitude is proportional with the variation speed of the inductor magnetic flux.
The interaction forces between the inductor magnetic field and the induced currents draw into motion the electroconductor fluids, to which it is added the thermal effect of the induced currents.
There follows an example of constructing the device, which represents the construction scheme of a multifunctional electromagnetic device. The vibrating massage device is formed of the bath tub number 1, the
ferrofluid pillow number 2, the reinforcement number 3, with a ferromagnetic support function, and the diphase winding number 4 for producing the progressive magnetic field of displacement in the sense of the phase succession.
Bath tub number 1 is made of dielectric waterproof materials, like polyethylene, polypropylene, polystyrene or polycarbonates. The O opening at the bottom of the bath tube number 1 is used for evacuating the liquids by detaching the plug that closes it. Pillow number 2 is made of rubber or plastics, being compartmentalized by interior walls which have openings for letting the ferrofluid moving from one compartment to the others.
The mechanical resistance of pillow number 2 is increased by placing it inside a cover made of textiles.
Reinforcement number 3 is made of iron - silicon sheet plates, laminated at cold and isolated with varnish, but one can also use ferrites, to decrease, at high frequencies, the energetic losses through the hysteresis effect and turbine currents. Diphase winding number 4 is made of copper wire isolated with varnish, being put in the notches of the ferromagnetic holder. The phase difference of π/2 rad of the electric currents that is to be found in the two phases of the winding number 4 is assured by an electrolytic condenser C of great capacity or even by a battery of condensers parallel connected, whose equivalent capacity is obtained by the addition of the capacities of the condensers of the derivation group. Each phase of winding 4 is composed of many reels, connected in series and alternatively wound now in one sense and then in the other, with the beginning extremities of the phase windings tied separately to the electric alimentation terminals, while the end extremities of the phase windings are connected together to the null conductor. The electric alimentation is done from the alternative current network through an electric auto-transformer and a frequency switch, equipment that enables the adjustment of the electric parameters.
The resulting magnetic field produces mechanical waves with double frequency in the volume of the ferrofluid from pillow number 2, which are transmitted through its flexible walls, and if in the bath tube number 1 there is a salts solution, which contains positive and negative ions resulted from the electrolytic dissociation process, there are induced electromotive tensions and electric currents, whose amplitude is in proportion with the variation speed of the inductive magnetic flux. There are various ways of using the electromagnetic vibratory massage device, from the simple bathing with warm water and soap to the mud bath or concentrated salts solution physiotherapy, and also by exposing the body to the action of the magnetic field produced by the electric currents that move through the diphase winding, and whose frequency can be modified at various values with the help of the frequency converters. At high frequencies, the magnetic field has a benefic action on the body by warming the tissues, stimulating the metabolism and even destroying and replacing some affected (ailing) cells through the activation of the biologic functions of the healthy cells. After the removal of the pillow with ferrofluid number 2, the patient that is under treatment with electromagnetic flux lies down in the bath tube number 1 with the ailing part of the body near the magnetic field source number 4. The pillow with ferrofluid number 2 is placed under the patient at the end of the treatment session for a massage at low frequencies, determined with the help of the frequencies converter. The electromagnetic vibratory massage device can also be used for creating a medium of saturated vapours in a tight space, and in this case the bath tube number 1 is covered with a lid or an impermeable foil - with an opening for the head of the patient - after which there is introduced, through the O opening, warm water or even steam from an exterior source, having the output and temperature permanently checked, under the bearable limits of the body. The alternation of cold and warm water is an option for revitalizing the body.
The treatment can be completed by exposing the patient to overpressure, underpressure and even controlled variations of pressure, processes realized by introducing and evacuating the air through the O opening with the help of a pump. For avoiding accidents, the complex treatment is to be done only under the surveillance of a qualified medical staff.
Multifunctional asynchronous electrical machine
The technical solution for electric operations refers to a multifunctional asynchronous electrical machine, capable of executing diverse movements, from rotation and translation, to compound movement of the helical type, which is especially used as an electric motor in the field of electric operations, but as an electromagnetic brake and even an electric generator. At the moment the asynchronous electric engine with a spinning magnetic field which, although has a simpler build than the synchro and allows to regulate the revolution, cannot execute other movements than rotation, which limits its range of uses.
In the patent FR2606225 is presented an electric machine with a double air gap mainly made of stator, impeller and an intermediate electric cylindrical screen, in various constructive variants, the poliphased wrappings for spinning type magnetic fields (which although has an improved masy power, the mobile part only assures rotary motions). In order to execute translation motion, in today's method of electric operations linear asynchronous machines are used which, at equal strength, their rated capacity and power factor is smaller than the corresponding parameters of the spinning machine.
The technical solution proposed eliminates these disadvantages through the fact that the multifunctional electric asynchronous machine is fitted with an intermediary empty cylinder type impeller with both faces in short-circuit, disposed coaxial between the exterior stator (on which there are the polyphased winding for the spinning magnetic field) and interior stator (on which there are the polyphased winding that assures a progressive magnetic field of longitudinal translation on the direction of the succession of the phases).
Further is given an example of achieving the technical solution, which represents a section through a multifunctional electric asynchronous machine. The electric asynchronous machine prototype is mainly composed of an exterior stator 2, an interior stator 4 and an intermediary impeller 1, which are coaxially disposed.
The exterior stator 2 and impeller 1 are of empty cylinder type, and the interior stator 4 is of a full cylinder shape.
The spinning magnetic field is generated by the three-phase electric winding, arranged in the notches applied on the interior face of the stator 2, and the progressive translation magnetic field is produced by the 5 three-fazed winding, placed in the notches applied in the lateral surface of the 4 stator.
The intermediary rotor 1 has both faces in short circuit , squirrel cage type for the exterior face, an assembly of parallel and equidistant conductor rings for the interior face.
The 3 and 5 three-phase winding (with the role of electric circuits) are made of copper wire isolated with varnish, and the 2 and 4 feromagnetics supports, which make up the magnetic circuits, as well as the 1 intermediary rotor are made of electrotechnical steel plate cold laminated and isolated with varnish, to reduce the losses through hysteresis effect and flow vortexes. From a structural and functional point of view, the multifunctional asynchronous machine is a combination of a rotating electric asynchronous machine (unit 1 and 2) and a new constructive variant of asynchronous machine with linear action (unit 1 and 4) coupled between them through a common mobile part. As for the engine, the multifunctional asynchronous machine assumes electric power from the charging network, which it transforms in mechanical power through the interaction forces between the magnetic fields produced by the three-phase currents from the constantly and the currents induced into the rotors conductors. Further on only the structure is being presented and the way the unit made of rotor 1 and stator 4 will work, because rotating asynchronous electric machines are well-known at the level of today's technology, from specialty works for electric operations. The 5 three-phased winding is made of circular coils, placed parallel and equidistant on stator 4, in the notches applied on its lateral surface.
The coils for every phase of the charging tension are made from coils joined in series and alternatively wrapped, in one way or another. The beginning extremities of the phase winder are tied separately at the exterior terminals A, B and C, and the ending extremities are tied together at the O null coil.
The electrical charging from the three-phase network of alternative current can be made from a star fitting or a triangle fitting. The electric currents from the 5 three-phased winding can produce a progressive translation magnetic field on the longitudinal direction, whose magnetic induction in the gap air can be estimated through relation: B(x,t) ≈ Bmsin(ωt - 2πx/d), where the symbols used have the following significance:
Bm = the maximum value or the magnetic induction amplitude;
ω = the alternative current throb;
x = the coordinate of the current point on a longitudinal reference axis;
d = the distance between two successive points, on a longitudinal direction, in which the magnetic induction vector oscillates in a phase.
The magnetic induction is a double periodic dimension (in time with period T=2π/ω, in space with period d) which (in the given example) coincides with the distance on which are disposed six circular consecutive coils, two coils each (with opposite winding effect) for each phase.
The points in which the magnetic induction vector has a constant phase, checks the relation:
Φ = ωt - 2πx/d = constant.
By deriving the preceding relation in respect to time we obtain the translation speed of the magnetic field:
v = dx/dt = ωd/2π = d/T.
The variable magnetic field made by the 5 three-phase winding induces in the conductive rings of the mobile part 1 alternative electromotive tensions in proportion with the variation speed of the magnetic flow through surfaces delimited by the rings. The magnetic fields inductor and induced, interact among themselves through electromagnetic forces whose resultant has a unnull longitudinal component, which assures the translation motion of the mobile part 1 of the multifunctional asynchronous machine.
The rotation movement of the mobile part 1 is assured by the torque of the interaction forces rotating magnetic field made by the three-phase winding 3 and the magnetic field produced by the currents induced into the squirrel cage type electric circuit conductors. It's easy to understand, on the basis of the law of electromagnetic induction and the principal of effect overlapping, the independent actions of the magnetic fields produced by the three-phase winding 3 and 5 on the faces in the short-circuit of the intermediary rotor. The whirling magnetic field produced by the three-phase winding 3 has the field lines arranged normally on the surfaces limited by the squirrel cage conductors in its vicinity, in which it induces intense electric currents. The interaction forces which brings forth the torque engine are perpendicular to the rotation axis, unlike the translation magnetic field produced by three-phase winding 5 (which induces intense electric currents only in the conductor rings of mobile part 1, their surfaces being mostly recrossed by field lines, the interaction forces have in this case a component parallel with the rotation axis, which assure the translation motion). In other words, the rotating magnetic field and the translation magnetic field, having perpendicular field lines, will act through perpendicular forces on the mobile part, which has the squirrel cage conductors on the planes normally arranged on the planes of the conductor rings.
Through the make up of the translation motion with the rotation one we obtain a resulting motion of the mobile part 1 of helical type.
Another constructive variant of the multifunctional electric machine is obtained through mutual changing winding positions 3 and 5, in which case the lateral exterior side of the mobile part 1 is fitted with conductor rings and the interior side is fitted with squirrel cage type electric circuit.
Even the mobile part 1, with both sides in short-circuit, can be replaced with a rotor having fitted on the sides permanent magnets or feromagnetics pieces which assure a variable reluctance, their shape being adapted to the type of polyphased winding which it neighbours. To avoid electrical overcharges and mechanic shocks, the starting of the asynchronous engines with the rotor in short-circuit can be achieved by connecting directly to the network, only for small powers, and for powers bigger than 10kW, the starting is made through some autochanger, some star-triangle switches or some coils tied in series with three-phased statoric windings.
Adjusting the revolution and the speed of the longitudinal displacement of the mobile part 1 can be made through the variation of the amplitude and frequency of the tensions applied to the winding coils 3 and 5, with the help of rheostats, respective of some frequency converters. The alternative motion of mobile part 4 can be obtained with the help of tripolar electric switches (to change the order of phase succession) or even through the usage of some stators which present symmetric sectors with inversion in the order of phase succession.
For the production of large revolutions we can use a modified version of the asynchronous motor, in which the intermediary rotor 1 is fitted on both sides with squirrel cage type electric circuits, and stator 4 and coil 5 are replaced with a interior rotor on which a three-phase winding is placed for generating the second rotating field.
In this case, the global effect is cumulative if the two rotating fields determine the same motion direction as the interior rotor. Multifunctional asynchronous electric machines are reversible, the rotation and translation speed (also known as synchronism speed) of the rotating magnetic field respective progressive, represent limit values for the proceeding from the motor system to the electric generator system and vice versa.
As for the engine, the rotation and translation speed of the mobile part 1 are less than the corresponding synchronism speed, and by overlapping of this limit values it shifts to the electric generator system.
Hindering asynchronous motors can be realized, not only through shifting to generator system with energy recovery, when induced currents create a resistant torque, but also through reversed connection or even through continuous current injection. There are different variants for asynchronous electric machines which differ through the number of fazes and the manner of arranging of the electric circuits, as well as through the dimensions and the nature of the materials from which the components are made of. It is easy to imagine a multifunctional electric motor of a step by step type. Multifunctional asynchronous motors are especially useful in robotics, and generally in automatization, as elements of executions in automatic regulation systems. By associating with processing computers, we can accomplish automatic systems which can carry out complex functions.
The cancer has to be defeated
The cancer has made a lot of victims, and unfortunatelly he still continues to do this, without being stopped by the medicine. Beside cardiovascular diseases and HIV infection, the issue of cancer belongs first of all to the field of public health and scientifical medical research on which solving take part General Biology, Molecular Biology, Biochemistry, Biophysics, Immunology, Endocrinology, Virology, human clinic, and so on.
The cancer is an evolutive disease produced by various pathological agents (ionizing radiations, chemical carcinogens, oncogenic viruses) which alter the reglator genes of the cellular cycle.
Among the implicative environmental causes there are mentioned:
- ionizing radiations [undulatory (X, γ), corpuscular and (e, p)];
- synthetic or natural chemical substances [tobacco, alcohol, arsenic and its cognates, chromium and its cognates, benzidine, benzene, chlornaphazine, melphalan, yperite, vinil chloride (mustard gas)];
- RNA viruses (oncarnaviruses) but also DNA viruses (Papova viruses, herpes viruses, pox viruses, adenoviruses);
- Germs (corynebacteria) and some of the parasites (protozoa and helmits).
Like carcinogens, the viruruses can produce malignant mutations, rather being a causal latent agent, than an active one. It is being supposed that the viruses are present in the cells in a passive state, and the virulent action is stimulated by some external agents (radiations and oncogene substances) or internal (genetic mutations, mutations of the metabolism or of the hormonnal balance). According to some specialists, the oncogene substances are increasing the amount of mutations in the damaged tissues, by rendering them a selective advantage in the process of cell growth regulation, as resulted in some demographic genetic studies. There are some fears as the fact that some surface-active agents, used as launders or alimentary additives can act as activating agents in the process of developing cancer. The cancer can appear in various forms and it is favoured by stress and an inadequate lifestyle. He produces chaos in the organism, by altering the natural biological configurations and by intervening into the pathway of evolution which is inscribed in the genetic programme.
The oncogenic cells are anarchical proliferating and can give birth to localized tumors (benign and malignant), or they can spread to other locations through metastasis. The tumors have a common feature, the abnormalities that are formed because of the abnormal cellular proliferation. If the benign tumors are relatively harmless, having a slow strictly localized evolution, exceptional reappearances and a high-level of histocitologic differentiation, the malignant tumors are characterized by a rapid growth, local invasion, local and zonal spreading, lack of cell differentiation, reappearance after surgeries, frequently leading to the death of the patient, especially when they are not treated on time. Of course, the etiology of the cancer, its diagnosis and treatment are strictly connected to the researches performed in order to find out the immunologic differences between malignant and normal cells.
It is largely considered that the proteic specific substances, which give identity to cells, are being altered by carcinogen agents, the outcoming configurations being self-reproductive. The anti-bodies are coming in, but they become harmless as they adapt. It is even possible that the malign cell not to be recognized by the adjusting growth mechanisms and they can proliferate without control. In cancer diagnosis, except the clinical scanning, it is made the histologic examination of a tissue sample (biopsy) collected from the neoplasm.
The citologic exam is based on the morphological alteration of the cells (nuclear, citoplasmatic, of mass and shape), using impecabil techniques of harvesting (by exfoliation and puncture), fixation and colouring (the Papa Nicolau and May-Gründwald-Giemsa methods), the analysis under the optic microscop, sometimes supplemented by specific methods such as fluorescent microscopy or phase contrast microscopy.
At the present moment there is the possibility of precociously detecting the cancer by emphasizing some biological indicators related to tumors (malignant "marker") such as [regular substances exceedingly synthetised (hormones, enzymes, proteins), oncofetal or differentiation substances (CAE, AFP, POA, CALA, EMA), tumor specific transplantation antigen (TSTA) or tumor-associated transplantation antigen (TATA), chromozomial alteration (Philadelphia chromozome) and so on]. The fight against cancer has to be efficiently organized, by applying some mass diagnosis tests, such as the so called Schultz-Dale test, which consists in the tracking down the antigen components in the blood of those who suffer from neoplazic affections.
A sanitary education is also necessary for the population which must ask for medical care as soon as the characteristic symptoms are present. Although there have been tremendous efforts and a great deal of research, the cancer mechanisms are still a puzzle and at the present moment there is no efficient form of treatment against all its forms of manifestation. The interferon and anti-cancer vaccines can only increase the hull resistance or slow the cancerous cell division. Chemotherapy and radiation therapy are frequently used, although chemical drugs and the X-rays harm not only the cancerous cell, but also the healthy tissue, they lead to immuno suppression, skin rashes and complications, sterility and congenital malformations. Microwave therapy has less harmful effects, but it is less efficient. In some extreme situations one can have his body mutilated and an emotional impact on the personality as a result to the surgeries meant to eradicate the malignant tumors.
In the cancer treatment, surgery and radiation therapy only can not be considered long term solutions, although some technical improvements are to be expected. It has been proven experimentally that irradiation is more efficient in the presence of certain oxygen concentrations. The researchers are relying on the destruction of cancerous cells through chemotherapy or by using the immune mechanism.
At the present, in chemotherapy there are used the metabolic antagonists of the purine and of nucleic acids such as fluoro-5-uracil, fluoro-5-deoxyuridine and aza-6-uracil or even alkylation agents based on chloroethylamine and triethylenemelamine (TEM). In order to administrate a high dose of antimitotic drugs without affecting the bone marrow cells, a local perfusion is being applied, due to an extracorporeal circulation.
The combination between an antimitotic agent and irradiation gives better results in comparison with each of these means are used individually. The research on irradiation side-effects and on the use of substances that harm the metabolic processes of the cancerous cells are being enhanced especially by obstructing the Krebs cycle or by oxidation of hexose monophosphate. During their growth the cancerous cells are using glutamine which provides some elements of the nucleic acids. Glutamine antagonists together with immunisation mechanisms of the body, can contribute to cancerous cells' destruction, especially when irradiation is applied or high oxygen concentrations are used. Chemotherapy does its best in exploiting the significant differencies between the nucleic acids of the cancerous cells and the regular ones, such as order of the pyrimidic bases.
It is well known that DNA molecules of nucleic acid form a double helic strand, having the pyrimidic bases oriented in the inside, while on the outside are arranged the dezoxy-2-D-ribofuranosis and its corresponding phosphate, ensuring its stability through hydrogen bondings.
The chemical agents which attack the modified nucleotide groups or disturb the coupling of nucleic acids bases in the carcinogene cells, are both offering new possibilities for chemotherapy and hope for important advances in the battle against cancer eradication. In the near future, the cancer therapy might benefit from products based on bacteria and parasite fungus, such as those that lead to plant cancer, or even on the extracts from outgrowth ("gale") occured on leaves due to the insects stings. This hypothesis is based on the studies published in 1982 by Helen Coley Nauts from Cancer Research Institute Inc. New York, concerning the role of bacterial infections upon the cancer therapy.The female author tries to establish a connection among bacterial infections and the interferon secretion, plus the positive effect of fever in the cancer thermotherapy. An interesting point of view is the assumption that bacteria are fighting against the growth of cancer cells by using iron, wich is indispensible for the development of cancer cells. Therefore, it is mandatory to study the disease incompatibility in order to obtain optimum results with applications in therapeutics. A new approach in cancer therapy is based upon the relationship between the genetic program and the division-biostructuring orientation spindle.
It is normal that an alive structure to be built on the ordered cells arrangement as basic units.
This arrangement is dictated by the program schemes of the division spindle orientation, in direct correlation with the division and cytodistinction frequencies. Moreover, bioinformation is materialising in structures and functions, but the mutual influence has also to be watched over. Let's not forget that through the resulted products, the genetic program is related to its own hystory. The reversed connection ensures accuracy, optimacy and movement to the next sequency. The action of some aggressive factors from physical and chemical ones to riboviruses, on the triple genetic relation information - structure - function, might lead to malignacy because the cell enters in an "infinite cycle" wich determines a tragic end. Experimentally was found that a polyphasic field configuration, such as the one produced by the rack of an asynchronous electric engine having adjustable frequency is extremely useful in intensive medical therapy of many diseases, because it shuffles the electroconducting biological liquids, favours the ion exchange, selectively eliminates ill cells, orientates the division spindle, activates and warms up the tissues.
The physical parameters of an electromagnetic field created by the complex stationary instruments or by personal electromagnetic belts with incorporated electrical source can be adjusted and optimised using special automatisation and calculation techniques. The electrical windings design rules, known in the asynchronous engines technology, may be applied in this case to obtain various configurations from rotational field to such forms as linear and helical ones. In order to reduce the overall size and to help body fit of the equipment, can be used windings realised from the flexible conductors or imprinted circuits, well isolated, inserted into segmented sacks that contain ferromagnetic material dust or even ferrofluids, for the electromagnetic field intensification.
Besides the previously presented method, the author brings into the specialists attention, an innovator solution for cancer treatment, based on an ultraintensive local procedure that allows healing of ill organs and tissues, with minimum of secondary effects on the entire body. Nowadays the methods of drug administration such as oral, perfusions, intravenous, intramuscular and hypodermic injections are well known. Nevertheless although these methods are easy to apply, they exhibit the risk of serious side reactions, manifested as various anatomic-physiological affections (fever, diarrhoea, nausea, queasiness, abdominal pains, stomatitis, skin eruptions, trembling, convulsions, apnoea, bronhospasm, photosensibilisation, cardiac disorders, hepatic and renal diseases, bone growth and haematopoiesis inhibition, sterility, muscular weakness, anaemia and so on).
The alternative solution proposed eliminates these disadvantages, since the ultraintensive treatment method is applied locally, only on the affected area by including the ill organ or tissue in an extrabody sanguine circuit fitted with an complex medical instrument, having not only a therapeutic role but also to ensure the necessary environment for the normal functioning of the biological processes.
Using this method, one can gain the following advantages:
- use of ultraintensive therapy by increasing the administrated drug doses;
- protection of healthy body parts against the negative effects of some drugs;
- decrease the risk of exposure to some drugs having certain counter indications;
- local stimulation of immune system and use of antibodies as transfer vectors for physico-chemical factors having destructive action against pathogenic agents.
AIDS is a disease caused by the HIV (Human Immunodeficiency Virus), an retrovirus witch destroys the T lymphocytes and seriously damages the immune system.
HIV has the genome composed of to two RNA chains included in a glycoprotein envelope of spherical shape, having a large antigen power. The viral RNA molecules are capable to dictate the DNA synthesis, using it to replicate.
The immune system of the organism strongly reacts against HIV by producing antibodies.
However, the invader viruses, when attacked by the antibodies become more virulent, are multiplying rapidly and infect a larger and larger number of healthy cells, specially the microphage ones.
The prophylaxy difficulties of AIDS are also determined by the existence of the virus genetic variations that change permanently, even in the same infected person.
Actually, for the treatment of this disease are used drugs that block the activity of reverse transcriptase enzyme, witch plays an essential role in the viral DNA synthesis or hampers the integration of viral DNA among the infected cells, as for example azidatymidine (AZT) and shiitak (LEM).
In the following part is presented an example of ultraintensive treatment method application shows the scheme for the treatment of a disease localised on a certain organ).
The therapeutic scheme is based on the idea of creating a secondary sanguine circuit for the ill organ O, by connecting the A artery and the vein V to the medical installation M with the aid of 4 tubes T1, T2, T3 and T4 fitted with serringe needle S1, S2, S3 and S4, or other devices on the terminals.
The separation between the secondary sangvin cycle and the circulatory system of the organism is obtained using the blocking devices D1, D2 by pressing the veins. The medical installation M has not only a therapeutic role, but also to ensure the necessary environment for the normal functioning of the biological processes and it is equipped with technical means for radiotherapy, chemotherapy, thermotherapy and also with devices and instruments for the feeding with glucose, dialysis or even and artificial heart and lung. There are two possibilities for applying this treatment procedure (in an unautonomous regime, respectively an autonomous one).
In the unautonomous regime the secondary sanguine cycle communicates with the circulatory body system.
The blood, that carries the nutritive substances and oxygen, is transported by A artery through the S1 needle and delivered through the T1 tube to the M medical installation where the proper treatment (disease specific) is administered (after receiving treatment, the blood continues his way through the T2 tube and the S2 needle to the ill organ). Through the S3 needle and T3 tube, the blood returns to the medical installation M.
From here, the drugs and the catabolism products are eliminated by dialysis, and reach to the circulatory body system through the T4 tube and the S4 needle. In the autonomous regime, the secondary sanguine cycle is isolated from the circulatory body system. In this case, the secondary cycle (previously nourished with healthy compatible blood) forms a closed curl O-S3-T3-M-T2-S2-O (the symbols are enclosed as shown, without further comments).
The autonomous regime is characterised by a high therapeutic efficiency, although it is more complex because the installation has to ensure not only the proper treatment (allopathic, alternative, thermic, by irradiation and so on) but also the artificial optimised environment for the development of biological processes, without affecting the ill organ. During the treatment, the medical installation M takes over the functions of heart, lung and kidneys by using the constitutive instruments. The drugs are administrated at the same time with glucose, in specific dose of active substance per body kilogram higher than the ones used in current medicine, in order that the therapeutic effect to be more intense and rapid. This is possible because the area where the adverse reactions of drugs take place is much more reduced. The only restriction of this method is that the administered dose to be 1,5 to 3 times lower than the minimum lethal dose supported by the ill organ.
The carcinogen cells may be destroyed by applying satisfactory higher concentrations of drugs prescribed by the specialist. In the case of an organism infected with HIV, the medical installation is connected to the principal veins of the circulatory system for the entire amount of blood to be circulated periodically through the instruments where receives the suitable treatment (drug administration, physical factors action and so on).
The ill cells are targets for the antibodies produced by the plasmocytes from the blood.
Specialists in medicine estimates around one million of different plasmocyte lines that originate from a common cellular source existing in the spleen. Each plasmocyte clone produces monoclonal antibodies for a single antigenic determinant. It worth to be mentioned that monoclonal antibodies can be produced "in vitro" by the hybridions cultures in much larger quantities and can be further used and inoculated into the blood.
In addition to the important role played in the body defence, the antibodies can be used for the early diagnosis of certain diseases, but also as transfer vectors for drugs, toxins or radioactive isotopes.
Thus the antitumour antibodies can be coupled with anticoagulant drugs such as metoraxate, ricine and so on.
Unfortunately, in order to not denature the antibodies the amount of drugs that may be used for coupling is very small. To overcome this disadvantage, usually are used liposomes (small lipid vesicles that can be attached to the antibodies through covalent bonds). The antibodies guide the liposomes coupled with drugs, to the target tumour cells. Another way to increase the antibodies effectiveness is their coupling with very powerful natural toxins.
The natural toxin is protean in its nature and contains two chains, one witch gives the toxicity, and another one that dictates the penetration into the cell. The chains responsible for the toxicity, if isolated, loose this capacity because they cannot penetrate into the cells. But if coupled with antibodies, they enter selectively into the target cell. In order to destroy the target cells infected with HIV, the intensive treatment with drugs may be associated with the progressive replacement of part of the infected blood with healthy blood originating from compatible donors. The ultraintensive treatment method is difficult to apply but it is indispensable in the case of special diseases that cannot be efficiently treated by more simple unsophisticated methods. For the adaptation of this method to the real therapeutic situations it is mandatory that specialists doctors from many fields to join together within a team.